"It is wrong to dare bring Turkey to its knees through threats over a pastor", Erdogan said in the Black Sea town of Unye.
"Shame on you, shame on you", he said in remarks directly addressed to Washington. "The US should not forget that it could lose a strong and honest partner like Turkey if it does not change its attitude", he was quoted as saying by Hurriyet daily.
A meeting on Friday unveiling a new economic approach by Turkey's finance minister Berat Albayrak, Erdogan's son-in-law, did little to offer support for the free-falling lira as investors sought concrete steps such as an interest rate hike to restore confidence. One U.S. dollar traded at 5.96 lira by 2:15 p.m.
"If you have dollars under your pillow, take them out". If there are euros, take these out.
"If they have their dollar, we have the people, we have Allah, " he said.
"Aksoy says Turkey "always backs the resolution of issues through diplomacy, dialogue, goodwill and mutual understanding", but would retaliate for Trump's decision".
According to a source in Erdogan's office, the two said they were pleased with the positive direction in their economic and trade ties and with the ongoing cooperation in the energy and defense sectors. Two days later, Secretary of State Mike Pompeo warned that Turkey that the "clock had run out" to release Brunson. Erdogan's speech caused the value of the lira to drop even further.More news: Don't miss the meteor shower
In an opinion article published in the New York Times on Saturday, Erdogan wrote that Turkey and the US had been strategic partners and North Atlantic Treaty Organisation allies for the past six decades and that his country had repeatedly come to America's aid.
The United States, the world's biggest steel importer, imposed tariffs of 10 percent on aluminum and 25 percent on steel in March for imports from a variety of countries. "Our relations with Turkey are not good at this time!" he said. "Failure to reverse this trend of unilateralism and disrespect will require us to start looking for new friends and allies", Erdogan said.
President Donald Trump said on Friday that he has authorised the doubling of steel and aluminium tariffs "with respect to Turkey".
The White House also cited currency movements in China last week when Trump called for a possible increase in tariff rates on Chinese imports.
Mr Erdogan said although the nations had been allies for decades, Turkey "now has alternatives".
He also condemned as "unacceptable, irrational and ultimately detrimental", the sanctions imposed by the United States on several Turkish cabinet members over the Brunson issue.
Turkish officials held talks in Washington this week but there was no breakthrough.
Turkey has vowed to retaliate, but its currency has steadily weakened, removing some of the bite of the tariffs by making Turkish goods cheaper for US consumers.