Mexico is now assured of a slot in the round of 16 and now joins hosts Russian Federation and Uruguay from Group A, France of Group B and Croatia in Group and Croatia of Group C. Mexico unsurprisingly overcame Germany in their opening game.
Oddsmakers favor Mexico, most likely due to its stirring performance last Sunday in its upset win over Germany and overall World Cup pedigree - nine wins, seven draws and just two losses in its last 18 World Cup group-stage games.
Only a Germany win will prevent South Korea being knocked out with a group game remaining. South Korea lost its opening match.
Everything about this matchup suggests Mexico will win.More news: Oil falls as Opec nears deal to raise production
Osorio's team started on the front foot, with Miguel Layun seeing plenty of the ball in wide positions. Bet on Mexico to win.
Vela nearly turned provider two minutes later with a neat ball into Layun, but the former Watford man lashed his effort over from close range. Chicharito's first goal in the competition was the insurance marker his team eventually needed to vanquish South Korea.
South Korea will face Germany at the same time in Kazan.
With little else to cheer in the match, the South Korean fans were lifted by an impressive injury-time strike from Tottenham forward Son Heung-min - their first goal of this World Cup - but it was too late to push for an equalizer.
Mexico so far is one of the teams that has a ideal run in the campaign and has conceded just one goa.