"Ireland are preparing for a Grand Slam - they don't need any extra motivation".
Jones also reshaped the back-row after tournament-ending injuries to Nathan Hughes and Courtney Lawes.
England back rower Sam Simmonds believes a chance to avenge last year's Six Nations defeat at Ireland was the flawless incentive for the outgoing champions to end their poor campaign on a positive note.
Their places were taken by Sam Simmonds in at No 8 and James Haskell, selected at openside, with Chris Robshaw moving across to blindside flanker.
Jones - who has been forced to make an apology after offensive comments about Wales and Ireland emerged this week - guided the team to back-to-back Six Nations titles but defeats to Scotland and France last weekend scuppered their hopes of a historic third successive championship triumph. Exeter's Dom Armand, the stand-out back rower in the Premiership this season but ignored by Jones since making his sole worldwide appearance off the bench in Argentina past year, is among the replacements. Jonathan Joseph has been recalled at outside centre. At the hub of the game they have got a Saracens combination: "Richard Wigglesworth and Owen Farrell are very used to playing with each other and so that smoothes the path for Owen Farrell having to adjust from 12 to 10 because the responsibilities are quite a bit different".
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"At halfback Danny (Care) plays off the back of quick ball, where as we think Wigglesworth can create some for us".
"I know it's probably at the stage of being boring, which we don't want to described as, but the bubble (in the team hotel) does mean we can focus on the job at hand rather than what someone says about us".
"The pressure on England is not about the comments, it is about winning on Saturday", Gatland said.
Ulster lock Henderson was forced to settle for a place on the bench against Scotland last week after returning from a hamstring injury that kept him out of the Wales game.
Ireland are seeking to emulate the teams of 1948 and 2009 by achieving just their third Grand Slam success. Scotland, who finish off in Rome, have eight points with Italy yet to register even a bonus point.