There has been much speculation about O'Brien's future in Houston, with the Texans struggling through a 4-11 season after winning back-to-back AFC South titles in 2015 and 2016.
Houston Texans general manager Rick Smith says he will take an immediate extended leave of absence to help his wife battle breast cancer.
Smith and his wife, Tiffany, have three children.
Smith has been tending to his wife throughout this season while she has undergone treatment in Arizona.
"I am eternally grateful to the McNair family for their unwavering support during this trying time", Smith said in a statement Sunday.More news: New year, blue Moon
Despite the injuries to names like JJ Watt, Deshaun Watson, and Whitney Mercilus that completed turned the season upside down, Bill O'Brien or GM Rick Smith will reportedly get their walking papers once the season is officially over, if a recent report of their relationship proves true.
Information from ESPN's Sarah Barshop was used in this report. O'Brien recently said that he would "never" quit his job as Houston's head coach, and fortunately for him, it looks like he won't even have to worry about that right now.
The great news is, Watson will have O'Brien, whom he prefers, coaching him next year. "I don't control that".
O'Brien has one season remaining on a five-year deal he signed when he became the Texans' coach in 2014.
After Sunday's loss to the Colts, O'Brien called his first losing season as an National Football League coach "absolutely brutal".