However, Yamaguchi has the better current world ranking - 2 to Sindhu's 3 - and her most recent win over Sindhu was a sound thrashing 21-14, 21-9.
Rio Olympic silver-medallist PV Sindhu showcased a brilliant performance as she kicked off her campaign at the Hong Kong Super Series with a comfortable straight game victory over Leung Yuet Yee in the women's singles event here on Wednesday.
The 22-year-old Sindhu has a 1-4 head-to-head record against the former world no.1. In the quarter finals, Sindhu may come face-to-face with China Open victor Akane Yamaguchi.
Sindhu dominated the game from the beginning, ending the game in less than 40 minutes.
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On the other hand, World No.6 Ratchanok has never reached the final here, her best performance being the semis in 2015, while Sindhu finished runner-up in the tournament previous year as she lost the summit clash in straight games to Tai Tzu-ying of Chinese Taipei.
Second seed Sindhu outclassed China Super Series Premier victor Yamaguchi 21-12, 21-19 in a matter of 37 minutes.
It will be their first meeting this year.