Boston staved off elimination and will play again Monday at Fenway Park, down 2-1 in the series. First pitch is scheduled for 1:08 p.m. local time, with Doug Fister taking the mound for the Red Sox against Charlie Morton for the Astros.
David Price pitched four scoreless innings of relief.
Houston starter Brad Peacock was knocked out of the game by Boston during the third inning when the Red Sox plated 3 runs to take a 4-3 lead. Red Sox right fielder Mookie Betts made a home-run saving catch at the wall; Astros right fielder Josh Reddick knocked a ball over the tricky curving wall near the foul pole, giving Jackie Bradley Jr. a three-run home run.More news: Belgian FA Reveals The Number Of Weeks Injured Marouane Fellaini Will Miss
Hanley Ramirez went four-for-four with three runs-batted-in and Sand Leon drive in another run for the Red Sox.
The 20-year-old became the youngest Red Sox player ever to homer in a playoff game and just the sixth player in major league player in history to do so in the post-season before turning 21.
It was the first postseason win for Boston since the 2013 World Series Game 6, after previous year being swept by Cleveland.