If one consulted the Royal family playbook, the chapter on types of spouses acceptable to live with a Mountbatten-Windsor or Wales heir to the throne, Markle's name would not be listed.
In the past few months, the 32-year-old prince has opened up about losing his mother, Princess Diana, when he was just 12-years-old, explaining how he dealt with his feelings and encouraging others to seek help.
"No child should be asked about this", said Harry.
"I intuitively know what my mother would like me to do and want to progress with work she couldn't complete", Harry added.
Whilst everyone does have a right to make their own way through life, it can not be easy when through no choice of your own you are born into a Royal Family whether in the United Kingdom or elsewhere.
But made a decision to carry out his royal duties because of the Queen.More news: India beat England by 35 runs
"If what Prince Harry says is true, we need a national debate about ending the monarchy", wrote the online, membership-based campaign Republic on Twitter.
But even when things started to improve, he questioned whether he wanted to be a royal at all, living life in what he called a "goldfish bowl".
"They are phenomenally lucky to have what they have, and will continue to enjoy it only by retaining the gratitude and respect of the Queen's subjects, which is not a given".
The remarkable comment by the prince was made in an interview with the US magazine Newsweek.
Most readers will understand the message the prince was presumably trying to get across-the burden of duty can indeed weigh heavily, Vanity Fair's Katie Nicholl said.
Asked whether he anxious that an ordinary Royal Family would take away The Firm's mystery, Harry replied: "It's a tricky balancing act. We don't want to turn up, shake hands but not get involved".
Expect to see a more buttoned-down Harry going forward.