The American rockers will take over the main Pyramid Stage, two years after frontman Dave Grohl fell off a stage and injured his leg, forcing the group to cancel their festival appearance.
Hundreds of normally tranquil revellers at the Silent Disco (a dance tent where people listen to music on headphones) started chanting his name to the tune of The White Stripes" "Seven Nation Army'.
They did so, he said, "because they were fed up with being told they don't matter and that their generation was going to pay more to get less in education, housing, health, pensions and everything else".
Nigel Farage has been trolled on Twitter for his response to Jeremy Corbyn's speech at Glastonbury Festival. "We went out and talked to people, we went out to meet people and you know what, we went out and debated people".
The Labour leader used his 4pm slot on the Pyramid Stage to appeal to equality, and an end to the division in wealth and poverty.
After thanking event organizer Michael Eavis for providing the setting, Corbyn opened with a short message for US President Donald Trump: "Build bridges not walls".More news: Death toll in Pakistan attacks climbs to 56
Jeremy Corbyn said he had been inspired by how many young people had got involved in politics as he addressed the crowd at the Glastonbury festival.
He also praised the festival for inspiring arts and music and for promoting the importance of protecting the environment.
He replied "Oh it's far too bad, I can't possibly tell you", he said, before adding: "Where's the nearest wheat field?"
The Labour leader included the policy to back renewal of Trident in his election manifesto in recognition of the fact that it is the party's policy to keep the nuclear deterrent.
Leader of the opposition Labour Party, Jeremy Corbyn speaks to supporters during a campaign rally at the Unite headquarters in London on September 20, 2016.
"Shake your chains to earth like dew, which in sleep had fallen on you".
Peter Hook, the bass player from Manchester bands Joy Division and New Order, led the crowd in reflecting on "our hopes and our prayers for life, love and freedom, the things we are here to celebrate".