India was put in to bat after losing the toss at The County Ground but looked impressive from the start as Mandhana, Raj and Poonam Raut did most of the damage in a total of 281 for three from 50 overs.
West Indies also come into the tournament with plenty of confidence having lifted the ICC Women's World Twenty20 just past year, as part of a hat-trick that included the ICC World Twenty20 won by the men's team and the ICC U19 Cricket World Cup taken home by their colts.
The captain of India's women's cricket team caught fans' attention during a World Cup game on Saturday by calmly reading a book as she waited to bat.
About marriage she says, "I'm not in a hurry to get married because of my age".
The 20-year-old Mandhana struck 11 fours and two sixes off 72 deliveries while Raut assumed the sheet anchor role, facing 134 balls and counting seven fours and a six. Her run out proved to be the turning point of the game as England was cruising when she was at the crease.
For England, middle-order batswoman Fran Wilson top scored with 81 runs off 75 balls and Heather Knight contributed 46 runs. But just when the going seemed good, Mandhana was sent packing by off-spinner Heather Knight. Captain Mithali scrore 71 preceding being dismissed off the last ball. "I realised the wicket isn't much of an assistance to the bowlers so I knew it would be challenging for England".More news: Red Sox retire No. 34 for Ortiz
Knight said the occasion didn't get to her side, adding: 'I didn't notice anything different in the warm-up or how the girls have been in the past few days.
India beat hosts England by 35 runs in the opening match.
Meanwhile in Bristol, 2000 champion New Zealand eased to a comfortable nine-wicket victory over Sri Lanka to open up its bid for the ICC Women's World Cup title in fine style.
"To win 100 caps for your country is a big achievement at any time but to do it at a World Cup would be even more special", said Satterthwaite.
Holly Huddleston produced a stunning second spell for the White Fearns to finish with figures of five for 35 to restrict Sri Lanka to just 188 for nine from its 50 overs.