Meanwhile, the Nasdaq Composite Index which has outperformed its peer equity benchmarks year to date, ended at a record, up 0.3% at 6,169, wrapping near its highs of the session. Health care and real estate companies fell more than the rest of the market.
Technology companies climbed the most, while financials managed a small gain.
"There's a lot of political data but not a lot of economic data that's changing the landscape", said Paul Nolte, portfolio manager at Kingsview Asset Management in Chicago.
The Dow Jones Industrial Average closed down 2.19 points, or 0.01 per cent, to 20,979.75, and the S&P 500 lost 1.65 points, or 0.07 per cent, to 2,400.67, easing from an intraday record high of 2,405.77.
MARKETS ABROAD: In Europe, France's CAC 40 rose 0.2 percent, Germany's DAX index gained 0.3 percent and the FTSE 100 rose 0.3 percent.
According to the National Association of Home Builders, the Housing Market Index for May rose to 70, which improved investors' confidence.
United States markets pushed further into record territory in early trade, with both the Nasdaq and S&P 500 indexes hitting new intra-day highs.More news: Medicaid Expansion Takes Center Stage in Senate Health Care Debate
Separately, the Federal Reserve said that industrial production at US factories, mines and utilities shot up 1% in April from March. The increase was more than twice what economists had expected.
Dow member Johnson & Johnson won 2.7 percent following an upgrade from J.P. Morgan, which projected stronger growth in J&J's pharma business due to expected new product approvals. The weakness was led by a big drop in construction of apartments, a volatile sector.
The company said it was facing a "challenging retail environment". Nine of the S&P 500's 11 main sectors finished in positive territory, with energy and materials stocks among the biggest gainers.
Oil and gas companies fluctuated with oil prices, which extended recent gains as Kuwait joined Russian Federation and Saudi Arabia in supporting prolonged supply cuts. This is 2.6 per cent below the revised March estimate of 1,203,000, but is 0.7 per cent above the April 2016 rate of 1,164,000.
Oil prices edged up about 0.7 per cent today, prompted by the dollar's decline and the expectation for a supply limit deal to extend into next year. At the same time, the euro is trading above $1.10 and the sterling is close to $1.30.
YIELDS: The 10-year Treasury yield ticked up to 2.34 percent from 2.33 percent late Friday. China's Shanghai Composite Index crept up by 0.2%, and Hong Kong's Hang Seng Index advanced by 0.9%. South Korea's Kospi index rose 0.2 percent.
The Nasdaq climbed to a fresh record on Tuesday (May 16), but the S&P 500 dipped as the oil rally stalled and investors questioned the prospects for President Donald Trump's agenda.