The statement did not specify the length of stay, but it said that the President's return to the country will be determined by his doctors in the UK.
After several reports revealed that Nigerian president Muhammad Buhari was having difficulties eating and drinking, his media team have revealed that he will be leaving Nigeria tonight for urgent medical treatment.
Buhari's trip is coming 57 days after he arrived from London.
Nation said the Economic and Financial Crimes Commission (EFCC) on Friday told the Federal High Court in Lagos that no one has come forward to claim the $43,449,947 (about N13 billion), N23, 218,000 and £27,800 (about N10.6milion) cash found in an apartment on Osborne Road, Ikoyi Lagos.
'The length of the President's stay in London will be determined by the doctors.
ABUJA Nigerian President Muhammadu Buhari will travel to London on Sunday night for follow-up medical tests, handing over power to his deputy Yemi Osibanjo, his office said.More news: Obama receiving Profile in Courage Award from Kennedys
He wrote: 'Electing Buhari was our first step to repaying the debt we owe the Muslim-North; we placated the Christain-Southwest with Osinbajo as the Vice President.
The announcement came shortly after 74-year-old President Muhammadu Buhari met at his official residence with the 82 Chibok schoolgirls freed this weekend from three years of captivity by Boko Haram extremists.
"He had planned to leave Sunday afternoon but made a decision to tarry a bit due to the arrival of 82 Chibok girls who arrived in Abuja earlier in the day".
Adesina however said the President had transmitted a letter to the National Assembly as required by law.
After his return from London earlier this year, Buhari had indicated that further checkups might be needed. "Government will continue to function normally under the able leadership of the vice-president", he said.