However, just two miles into the marathon, she was stopped by the race director, Jock Semple, who demanded that she hand over her bib and leave the race.
In 1967, Kathrine Switzer had made history by running the all-male race by registering as KV Switzer, which had hidden her gender.
Fifty years on, aged 70, Ms Switzer returned to the starting line wearing the same number.
An inspiring moment during this year's Boston Marathon has captured the hearts of millions.
Yesterday Ms Switzer, now 70, finished the marathon in the United States city once again, this time accompanied by hundreds of supporters who ran alongside her.
"And he got so angry that there was a girl in the race that he stopped the bus and jumped off it and ran after me and attacked me in the race and tried to pull off my bib numbers, screaming at me, 'Get the hell out of my race and give me those numbers'".
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It was the Boston Marathon yesterday, and it marks 50 years since an incredible event for runners and women everywhere.
A year later, then-20-year-old Switzer told her coach at Syracuse University, Arnie Briggs, about Gibb and said she wanted to run Boston. In fact, the received wisdom was that running would rob women of their only attribute - that they could breed - and if a delicate flower was to so much jog to the bus stop her womb might fall out.
The finish capped off a big weekend for Switzer, who ran with 125 charity runners for her 261 Fearless foundation.
Kathrine Switzer in 1967 (L) and finishing the race on Monday.
Some runners enter the marathon with the intent to win against others, but many athletes aim to compete against themselves, beating their best times or pushing themselves just to complete it.
"People have such an appreciation for what running has done for them and how it's changed their lives", said Switzer, who named her 261 Fearless foundation after the bib number that was almost torn from her back on the marathon course. In 2011, she was inducted into the National Women's Hall of Fame in Seneca Falls, New York, where they quote Laurel Thatcher Ulrich: "Well-behaved women seldom make history". "We have come a light year, really", she said.
Along with Granville, a wounded Marine, Staff Sergeant Jose Luis Sanchez, also finished the Boston Marathon on Monday with a prosthetic leg while carrying an American flag.