Letterman's favorite Pearl Jam song is "Yellow Ledbetter".
Letterman wasn't the only fan in the room: As Vedder thanked his wife during his speech, one male fan from a seat up high screamed, "I love you, Eddie!" "I can't begin to tell you what an honor and a privilege it is for me to be out of the house, honest to God", he said.
"So, climate change is real, not fake news", exclaimed the lead singer. The Chicago Cubs winning the World Series. Band members have said they're open to the idea but are leaving it up to Perry to decide.
You know you've got a true headliner when David Letterman is just the warm-up. "That's the kind of music activism that gives us all hope".
Snoop Dogg accepted an award on behalf of the late Tupac Shakur and said that beyond being a great friend, Shakur was "the greatest rapper of all time". They'd return numerous times in the years that followed on their support tours for Yield, Riot Act and their self-titled record which also got the Live on Letterman treatment in 2006.
Snoop Dogg was on hand to collect Tupac's trophy, more than two decades after he was shot dead in Las Vegas.
Also paying tribute to the rapper was Alicia Keys, who led a piano medley of "Ambitionz Az A Ridah", "I Ain't Mad At Cha", and "Changes", as well as Treach (from Naughty by Nature), YG and T.I., who closed with a rendition of "Keep Ya Head Up".
One of the night's most anticipated performances belonged to Journey.More news: Clinton's 2nd Call on Election Night: 'Mr. President, I'm Sorry'
Journey was reunited with former frontman Steve Perry, who left the band 12 years ago. "You're one in a million", Schon complimented Perry, who returned the favor by mentioning "the magic fingers of Schon's guitar".
Perry last performed with Journey back in 1991, but sang on their 1996 studio album, Trial By Fire.
The most daring statement of the night might have been when Joan Baez, the sole woman among the inductees, made a reference to United States President Donald Trump. "My granddaughter had no clue who I was until I took her backstage to a Taylor Swift concert", said Baez, who added that her granddaughter took a selfie with Swift and now had "newfound respect for her grandmother". The night's first inductee kicked things off with its cover of Berry's "Roll Over Beethoven".
"I never really felt like I was part of the band".
Lenny Kravitz honored his late friend Prince by tackling "When Doves Cry" and "The Cross".
The ceremony will air in edited form on HBO on April 29th.
Artists are eligible 25 years after their first release, and voted on by fans and experts.